Saturday, October 4

from 16:00 Registration

from 18:00 Dinner

19:30 Opening lecture

Robert Huber: Proteases and their natural inhibitors in basic science and medicine
Helmut Holzer Memorial Lecture

20:30 Get-together (in the Brdo castle)

Sunday, October 5

Morning Session I:

08:30 - 08:55 Judith Bond: Mutational analysis of structure, biosynthesis, and activation of astacin family metalloendopeptidases

08:55 - 09:20 Wolfram Bode: How TIMPs inhibit MMPs

09:20 - 09:45 Francesc X. Aviles: Structural determinants in the functionality of metallo-procarboxypeptidases

09:45 - 10:10 Shahriar Mobashery: Computational insight into structures, substrate preference and inhibition by protein inhibitors of human gelatinases

10:10 - 10:35 Howard C.Crawford: Tumorigenesis in metalloproteinase knock-out mice

10:35 - 11:00 Coffee break

11:00 - 11:25 Hiroshi Maeda: PMN collagenase activation in microbial infection

Morning Session II:

11:25 - 11:50 Bruce Korant: Cell killing by viral proteases - identification of site of action

11:50 - 12:15 Klaus von der Helm: HIV proteinase inhibitors as effective chemotherapy and the problem of resistance mutation

12:15 - 12:30 Janez Mavri: Irreversible inhibition of the HIV-1 protease: An ab-initio study

12:30 - 12:45 Abelardo M. Silva: structure and inhibition of plasmepsin Ii, a hemoglobin degrading enzyme from Plasmodium falciparum

Lunch break

Afternoon session I:

15:00 - 15:25 Andrej Hasilik: Human procathepsin D

15:25 - 15:50 Kenji Yamamoto: Roles of cathepsin E and cathepsin D in neuronal death mechanisms

15:50 - 16:15 Lowri H. Phylip: Protein inhibitors of aspartic proteinases

16:15 - 16:40 Andrej Sali: Proteases in baker's yeast: A genome analysis

Coffee break

Afternoon session II:

17:00 - 17:25 Makoto Sasaki: Selective neuronal death induced by activation of nuclear pro -calpain under conditions of hypoxia

17:25 - 17:50 Seiichi Kawashima: Calpainolysis and lens cataractogenesis

17:50 - 18:15 Peter Friedrich: Activation mechanism of calpains from mammals and Drosophila

18:15 - 18:40 Nechama S. Kosower: The calpain-calpastatin system in myoblast differentiation and fusion: Implications for other biological systems

Dinner

Evening session:

20:00 - 20:30 Wolfgang P. Baumeister: Tricorn protease-the core of a modular proteolytic system

20:30 - 20:55 Jennifer Rivett: Proteasome localization and the effects of interferon

20:55 - 21:20 Sibylle Jäger: The active sites of the eukaryotic proteasome and their involvement in subunit precursor processing

21:20 - 22:20 Poster session I (posters P1-P30 approx.)

Monday, October 6

Morning Session I:

08:30 - 08:55 Alan J.Barrett: Cysteine peptidases old and new

08:55 - 09:20 Clive Dennison: Lysosomes and lysosomal proteolysis revisited

09:20 - 09:45 Eiki Kominami: Intracellular processing of cathepsins and their inclusion into lysosomes and phagosomes

09:45 - 10:10 Robert W.Mason: Targeted protease inhibitors identify endosomal proteases

10:10 - 10:35 Dusan Turk: Crystal structure of porcine cathepsin H determined at 2.1 Å resolution

10:35 - 11:00 Coffee break

Morning Session II

11:00 - 11:25 Nobuhiko Katunuma: The mechanisms and regulation of antigen processing by cathepsin B for various immuno-responces

11:25 - 11:50 John Mort: Endopeptidase and exopeptidase activities of cathepsin B and the biological consequences

11:50 - 12:15 Boris Turk: pH as an important factor for the regulation of activity of lysosomal cysteine proteinases

12:15 - 12:40 Gwendolyn Spizz: MARCKS: A protein kinase C regulated cellular substrate for cathepsin B

12:40 - 13:00 Bernd Wiederanders: The various functions of cysteine peptidase propeptides

13:00 - 13:20 Antonio Baici: Who drills the holes in osteoarthritic cartilage? The misdeeds of cathepsin B

Lunch break

Afternoon session I:

15:00 - 15:25 Bonnie Sloane: Regulation of expression, localization and function of cathepsin B: Significance in malignant progression

15:25 - 15:50 Tamara Lah: Cysteine proteinase inhibitors and cathepsins in breast tumor progression

15:50 - 16:15 Janko Kos: Clinical relevance of cathepsins and their inhibitors in cancer and some other diseases

16:15 - 16:40 Lukas Mach: Murine squamous carcinoma cells require misrouted lysosomal cysteine proteinases for invasion through basement membranes

Coffee break

Afternoon session II:

17:00 - 17:25 Ennes Auerswald: Chicken cystatin variants:what did they tell us?

17:25 - 17:50 Magnus Abrahamson: Novel human cystatins

17:50 - 18:05 Georgia Sotiropoulou: Cloning, expression and functional characterization of cystatin M and protease M

18:05 - 18:30 Brigita Lenarcic: A thyroglobulin type-1 domain inhibitors of cysteine proteinases

18:30 - 18:55 Maarten Jongsma: Inhibitor-insensitive proteases of insect pests

Dinner

Evening session:

20:30 - 20:55 Guy Salvesen: Regulation of caspase activation and activity

21:00 - 22:00 Poster session II (P31-P60)

Tuesday, October 7

Morning Session I:

08:30 - 08:55 Manfred Schmitt: The plasminogen activator system, a new target for tumor therapy

08:55 - 09:20 Nils Brünner: The urokinase plasminogen activator receptor in blood from cancer patients

09:20 - 09:45 Ernst M. Bergmann: Structure/function relationship in the cymotrypsin-like cysteine proteinases of positive-sense, single-stranded RNA viruses

09:45 - 10:10 Coffee break

Morning Session II:

10:10 - 10:35 Jan Potempa: Clinical implications of interaction between Porphyromonas gingivalis proteinases (gingipains) and blood coagulation cascade

10:35 - 10:55 Francis Gauthier: Substrate specificity and regulation of trypanosomal cysteine proteinases

10:55 - 11:15 Theresa H.T. Coetzer: Cysteine and serine proteases as targets for trypanocidal agents

11:15 - 11:30 Maria Lalioti: A dodecamer repeat expansion in the cystatin B gene is the most common mutation in progressive myoclonus epilepsy (EPM1)

11:30 - 11:55 Shoichi Ishiura: Proteases involved in the abnormal processing of Alzheimer's disease amyloid precursor protein

Lunch break

14:00 - 18:30 Excursion: Visit to Ljubljana, the capital of Slovenia

19:00 Conference dinner

Wednesday, October 8

Morning Session I:

08:30 - 08:55 Hiroshi Kido: Role of tryptase TL2 in T cell activation: implications for function both as protease and molecular chaperone

08:55 - 09:20 Valentin Stepanov: Glutamyl endopeptidases

09:20 - 09:45 Steve Olson: New insights into the novel mechanism of proteinase inhibition by serpin family inhibitors

09:45 - 10:10 Joseph G. Bieth: Regulation of serpin activity

10:10 - 10:30 Coffee break

Morning Session II:

10:30 - 10:55 Christian P. Sommerhoff: Novel proteinase inhibitors from the medical leech: properties, structures and tools to elucidate pathomechanisms

10:55 - 11:20 Gerald Reeck: The corn inhibitor of activated Hageman factor: Three-dimensional structure and functional properties of reactive-site variants

11:20 - 11:45 KeWon Kang: The guamerin-derived synthetic peptide on elastase and acute pancreatitis

11:45: Closing of the Symposium

Lunch

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